{"@context":"https://schema.org","@type":"Product","name":"Wholesale: 4 pack of Methylfolate 7.5+ Active B12","image":["https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methylfolate-7.5__4-pack.jpg?v=1760521394","https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methylfolate-7.5__bottle_capsules.jpg?v=1768210790","https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methylfolate-7.5__all-sides.jpg?v=1769080952","https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methylfolate-7.5__capsules.jpg?v=1760521425","https://cdn.shopify.com/s/files/1/0264/6369/9018/files/M7.5_-COA-T222A-DOM-Feb2024.webp?v=1773395154"],"description":"

Description

Note: Coupon Codes cannot be used with Discounted Bundles or Wholesale products.

Methylfolate 7.5 mg - Ultrapure calcium salt crystalline L-methylfolate + two well-tolerated forms of Active B12

Methyl-Life® products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.

Every serving in Methyl-Life’s® Methylfolate 7.5+ product contains a high dose (7.5 mg) of L-Methylfolate as internationally-patented Magnafolate® and 2.5 mg of Active B12 (as both Hydroxocobalamin and Adenosylcobalamin). We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.

\nHydroxocobalamin – Helps in pain sensitivity (chronic fatigue, fibromyalgia & COMT mutations may benefit), “brain fog”, detoxifying perioxynitrites or superoxides (bad guys), as well as pernicious anemia. The body converts Hydroxocobalamin into Methylcobalamin and Adenosylcobalamin.
\nAdenosylcobalamin – Helps in muscle recovery, mitochondrial support, repairing the myelin sheath, and again helps with anemia.

Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.

In recent studies Magnafolate® PRO showed significantly greater purity, stability and potency results when compared against competing brands Quatrefolic® and Extrafolate®. This is because Magnafolate® is built on a calcium crystalline molecule structure just like the pharmaceutical brand of L-Methylfolate. So if you’re truly looking for professional strength, look no further. Read more about Magnafolate's® superiority.

Methyl-Life® is honored to have been the first company in the USA to offer this uniquely pure and superior form of L-Methylfolate, (Magnafolate®), to our customers for over 5 years now. And we remain proud that we can offer such an exceptional product line at such an affordable price point (because as a family-owned company, we know this is important to you). No other competitor sells a comparable product for less. We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.

Spoiler alert ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf.

Methyl-Life® Methylfolate 7.5+ was formulated, especially for the people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better.

High doses of L-Methylfolate + Active B12s are designed to promote optimal neurotransmitter balance and function which may positively affect mood. It can also convert homocysteine into methionine which can support cardiovascular health and protect against anemia. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant). Talk to your doctor to determine, if taking high doses of L-Methylfolate and B12 is the right combination for you.

Dosage
\n

WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.

How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.

Dr. Amy Yasko recommends a specific form of B12 based on your genetics, if you know the status of your COMT 158 and VDR Taq variants.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

COMT V158M	VDR Taq	B12 Types That Should Be Tolerated
– –	+ + (TT)	All 3 types of B12
– –	+ – (Tt)	All 3 types of B12 with less Methylcobalamin
– –	– – (tt)	Hydroxocobalamin and Adenosylcobalamin
+ –	+ +	All 3 types of B12 with less Methylcobalamin
+ –	+ –	Hydroxocobalamin and Adenosylcobalamin
+ –	– –	Hydroxocobalamin and Adenosylcobalamin
+ +	+ +	Hydroxocobalamin and Adenosylcobalamin
+ +	+ –	Hydroxocobalamin and Adenosylcobalamin
+ +	– –	Mostly Hydroxocobalamin

SUPPLEMENT FACTS
\n

\nSUGGESTED USE: Ask your doctor. Visit https://methyl-life.com/dosage
\n

\n
Bite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.
\n

\n
Great for teeth, not for animals (contains xylitol).

\n
\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

SUPPLEMENT FACTS
\n Serving Size: 1 Chewable Tablet \n
90 servings per container\n	Amount per Serving	% Daily Value
Folate	7,500 mcg	1,875% (Total)
(as 6S-5-Methyltetrahydrofolate, Calcium as Magnafolate®)	\n \n	\n \n
Vitamin B12	2,500 mcg	41,667% (Total)
(as Hydroxocobalamin)	1,500 mcg
(as Adenosylcobalamin)	1,000 mcg

\n
\n

\nOTHER INGREDIENTS: xylitol (from non-GMO hardwoods), microcrystalline cellulose, stearic acid, silicon dioxide, less than 1% dextrose, peppermint oil, natural FEMA GRAS aromatics.

\n

PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.

\n
\n

Research

\n\n

FAQ'S

$\"Methylfolate$ What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

$\"Methylfolate$ Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?

No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 & 4 of his video seminar.

You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.
\n

You'll find our MTHFR Newbies page is very helpful as well. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

$\"Methylfolate$ What do doctors have to say about MTHFR and how to treat it?

Go to A Doctor Explains and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.

$\"Methylfolate$ How can I get more information on MTHFR?

check out our Help for MTHFR Newbies page.

$\"Methylfolate$ Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?

Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.

$\"Vitamin$ What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

$\"Vitamin$ What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).

$\"Vitamin$ What does sublingual mean and why isn’t your product labeled as “sublingual”?

It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).

\n
\n

Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).

\n
\n

Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.

$\"Vitamin$ My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxocobalamin, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxocobalamin, and from there the hydroxocobalamin has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

$\"Vitamin$ I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form to begin with):

Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
And Dr. Amy Yasko talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

COMT V158M	VDR Taq	B12 Types That Should Be Tolerated
– –	+ + (TT)	All 3 types of B12
– –	+ – (Tt)	All 3 types of B12 with less Methylcobalamin
– –	– – (tt)	Hydroxocobalamin and Adenosylcobalamin
+ –	+ +	All 3 types of B12 with less Methylcobalamin
+ –	+ –	Hydroxocobalamin and Adenosylcobalamin
+ –	– –	Hydroxocobalamin and Adenosylcobalamin
+ +	+ +	Hydroxocobalamin and Adenosylcobalamin
+ +	+ –	Hydroxocobalamin and Adenosylcobalamin
+ +	– –	Mostly Hydroxocobalamin

","brand":{"@type":"Brand","name":"Methyl-Life™ Supplements"},"dateModified":"2026-05-09T04:12:24.963648","offers":{"@type":"AggregateOffer","lowPrice":168,"highPrice":168,"priceCurrency":"USD","priceValidUntil":"2026-06-21","offerCount":1,"availability":"https://schema.org/InStock","url":"https://storestream.ai/products/wholesale-4-pack-of-methylfolate-75-active-b12-c2bd8b05","hasMerchantReturnPolicy":{"@type":"MerchantReturnPolicy","applicableCountry":"US","returnPolicyCategory":"https://schema.org/MerchantReturnFiniteReturnWindow","merchantReturnDays":30,"returnMethod":"https://schema.org/ReturnByMail","returnFees":"https://schema.org/FreeReturn"},"shippingDetails":{"@type":"OfferShippingDetails","shippingDestination":{"@type":"DefinedRegion","addressCountry":"US"},"shippingRate":{"@type":"MonetaryAmount","value":"0","currency":"USD"},"deliveryTime":{"@type":"ShippingDeliveryTime","handlingTime":{"@type":"QuantitativeValue","minValue":0,"maxValue":1,"unitCode":"DAY"},"transitTime":{"@type":"QuantitativeValue","minValue":1,"maxValue":7,"unitCode":"DAY"}}},"offers":[{"@type":"Offer","seller":{"@type":"Organization","name":"Methyl-Life"},"price":168,"priceCurrency":"USD","priceValidUntil":"2026-06-21","availability":"https://schema.org/InStock","url":"https://methyl-life.com/products/wholesale-methylfolate-7-5-mg-purest-l-methylfolate-active-b12s-3-month-supply-chewables","itemCondition":"https://schema.org/NewCondition","hasMerchantReturnPolicy":{"@type":"MerchantReturnPolicy","applicableCountry":"US","returnPolicyCategory":"https://schema.org/MerchantReturnFiniteReturnWindow","merchantReturnDays":30,"returnMethod":"https://schema.org/ReturnByMail","returnFees":"https://schema.org/FreeReturn"},"shippingDetails":{"@type":"OfferShippingDetails","shippingDestination":{"@type":"DefinedRegion","addressCountry":"US"},"shippingRate":{"@type":"MonetaryAmount","value":"0","currency":"USD"},"deliveryTime":{"@type":"ShippingDeliveryTime","handlingTime":{"@type":"QuantitativeValue","minValue":0,"maxValue":1,"unitCode":"DAY"},"transitTime":{"@type":"QuantitativeValue","minValue":1,"maxValue":7,"unitCode":"DAY"}}}}]}}

Description

Dosage\n

SUPPLEMENT FACTS\n

Research

FAQ'S

Dosage
\n

SUPPLEMENT FACTS
\n

Wholesale: 4 pack of Methylfolate 7.5+ Active B12

Where to Buy