Sirtuin 1 Activator - 60 capsules

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Switch On the Longevity Gene Activates and supports SIRT1*1-7 Promotes healthy aging at the cellular level*2,3,8-11 Strengthens the body’s antioxidant network*12 Helps maintain metabolic and inflammatory health*13 Boosts mitochondrial biogenesis and energy output*1,3 View Certificate of Analysis The Science of SIRT1 Inside every cell is a guardian protein called sirtuin 1 (SIRT1), short for Silent Information Regulator. It helps decide which parts of your DNA stay quiet and which stay active, helping cells adapt to stress, maintain energy efficiency, and resist the effects of aging. Commonly known as the "longevity switch," SIRT1 is involved in DNA repair, the removal of damaged cellular components, and the optimization of energy use. As we age, SIRT1 activity naturally declines due to factors such as oxidative stress, poor diet, disrupted sleep, and environmental challenges. This reduction is linked to diminished cellular resilience and many of the classic signs of aging. The good news is that certain food compounds can help support SIRT1 function. Plant-derived polyphenols such as resveratrol (from red grapes) and pterostilbene (from blueberries) are among the best-studied for their ability to activate SIRT1 and promote healthy cellular aging. These compounds mimic calorie restriction at the molecular level, helping to reactivate SIRT1 and restore youthful gene expression patterns. By boosting SIRT1 activity, they help shift cells into a protective, repair-focused state, supporting the body’s natural defenses as we age.*1-7 Why Resveratrol + Pterostilbene Work Better Together Resveratrol is well-known for supporting SIRT1, but the body clears it fast. The liver converts most of it into inactive metabolites within minutes. Blood levels fall quickly, so only a limited amount reaches cells. The effect on SIRT1 is meaningful, yet short-lived.*1-3,5-7 Pterostilbene shifts the profile. It is a close relative of resveratrol with two methyl groups that improve its performance. Up to 4× higher oral bioavailability* Greater lipophilicity for superior cellular penetration* Significantly longer half-life in the body (up to 7× longer than resveratrol)*4,14-16 When used together in a balanced ratio, the two ingredients work in sequence. Resveratrol supports a fast SIRT1 response. Pterostilbene keeps that response active for a longer period due to its greater stability. This provides steadier sirtuin pathway support than resveratrol alone.*1-7,14-16 What Makes Ours Better? 4:1 Polyphenol Complex: Balanced to reflect bioavailability differences between resveratrol and pterostilbene. Clinically Studied Forms: Includes the active trans form of resveratrol and pterostilbene for consistency and purity. Longevity Pathway Support: Engages SIRT1, AMPK and PGC-1α pathways linked to mitochondrial function and cellular upkeep.*1-7 Minimalist Formula: Uses only active polyphenols for a straightforward, clean profile.* The ProHealth Difference Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts. Triple Lab Tested: Verified three times by independent labs for purity and potency.  Full Transparency: Third-party test results published online for complete confidence. USA Manufactured: Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988. 100-Day Risk-Free Guarantee: If you’re not fully satisfied, we’ll refund your purchase in full. A Word from our Chief Science Officer "Resveratrol brought SIRT1 into the spotlight, but bioavailability has always limited its potential. By combining it with pterostilbene, we’re matching kinetics with biology — ensuring both rapid activation and sustained support of this key longevity pathway." Ingredient Info Trans-Resveratrol: The active, naturally occurring form of resveratrol that supports key cellular pathways involved in healthy aging.*Trans-Pterostilbene: A lipophilic stilbene that engages the SIRT1 pathway and complements resveratrol for steady cellular support.* References: Della Vedova L et al. Pharmaceuticals (Basel). 2025;18(2):138. Zhou DD et al. Subcell Biochem. 2024;107:183-203. Li YR et al. Biofactors. 2018;44(1):69-82. Wood JG et al. Nature. 2004;430(7000):686-689. Kuršvietienė L et al. Medicina. 2016;52(3),148-155. Lakshminarasimhan M et al. Aging (Albany NY). 2013;5(3),151. Borra MT et al. J Biol Chem. 2005;280(17),17187-17195. Thaung Zaw JJ et al. Clin Nutr. 2021;40(3):820-829. Thaung Zaw JJ et al. Menopause. 2021;28(1):40-49. Wong RH et al. J Bone Miner Res. 2020;35(11):2121-2131. Thaung Zaw JJ et al. Nutrients. 2020;12(3):828. Chan EWC et al. J Appl Pharm Sci. 2019;9(7):124-129. Della Vedova L et a. Pharmaceuticals (Basel). 2025;18(2):138. Wang P, Sang S. Biofactors. 2018;44(1):16-25. Riche DM et al.  J Toxicol. 2013;2013:463595. Kapetanovic IM et al. Cancer Chemother Pharmacol. 2011;68(3):593-601. Supplement Facts Serving Size: 1 Capsule Servings Per Container: 60 Amount Per Serving %DV Veri-te® Trans-Resveratrol 200 mg † Trans-Pterostilbene 50 mg † † Percent Daily Values (DV) not established REV.10.25 Veri-te® is a registered trademark of the Lallemand group. OTHER INGREDIENTS: Rice flour, hypromellose (capsule). SUGGESTED DAILY USE: Take one (1) capsule per day with food. CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.

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