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Turn On Your Body's Collagen Switch

Activates natural collagen production*^1-4\n
Supports skin hydration, elasticity, and firmness*^1,3-5\n
Strengthens joints and connective tissue*⁶\n
Supports collagen density and structural resilience*^2,7,8\n
Promotes healthy aging from the inside-out*^1,2,6\n

Why Collagen Matters

Collagen is the body’s most abundant structural protein—found in skin, bones, joints, ligaments, and connective tissue. But as early as your 20s, collagen production begins to decline, dropping 1–1.5% per year.*¹ By your 40s, this results in visible and structural changes: skin loses firmness, joints feel weaker, and connective tissues become less resilient.*^1,9,10

To build collagen, your body relies on three key amino acids—glycine, proline, and hydroxyproline—arranged in a tightly wound triple helix. Of these, hydroxyproline plays the most critical role.^7,8

Meet Hydroxyproline—The Master Collagen Signal

Hydroxyproline is a rare and highly specialized amino acid found only in collagen. It plays a critical role in giving collagen its unique triple-helix shape—the very structure that allows collagen to be strong, stable, and resilient.^7,8

But hydroxyproline does more than build collagen—it activates it.*^2,4,12-14

When collagen begins to break down (like after exercise or with age), hydroxyproline is released into the bloodstream. This acts as a biological signal that alerts your body to ramp up new collagen production. In this way, hydroxyproline serves as the body’s built-in collagen switch, helping to restore and rebuild what’s been lost.*^2,4,12-14

By supplementing with hydroxyproline directly, you give your body the raw material—and the signal—it needs to boost collagen production as you age.*^1-4

Beyond Hydroxyproline: Complete Collagen Activation

Hydroxyproline is essential—but it’s not the whole story. Your body can also create its own hydroxyproline by converting the amino acid proline—a reaction that depends on vitamin C. That’s why Pro Collagen Activator delivers:

\nHydroxyproline to directly activate collagen synthesis*^2,4,12-14\n
\nProline to support natural hydroxyproline formation*^2,6,12,16\n
\nLiposomal Vitamin C to enhance proline conversion and collagen stability*¹⁵\n
\nCitrus Bioflavonoids to boost vitamin C absorption and help protect collagen*¹⁵\n

\nThis systems-level approach helps fuel collagen production from multiple angles—so your body has what it needs to build and sustain strong, healthy tissue.*^2,4,6,12-16

\n

What Sets Us Apart

\nNo Animal Ingredients: Made without animal-derived collagen or byproducts.
\nHigh-Dose Hydroxyproline: Equivalent to 5 grams of collagen peptides per serving.
\nFlexible + Stackable: Powerful enough to stand alone, or stack with collagen peptides for amplified results.*
\nSmarter Support: Features a small-molecule formula designed for superior absorption and optimal activation.*
\nRooted in Science: Formulated to activate the body’s own collagen switch.*

The ProHealth Difference

\nDoctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
\nTriple Lab Tested: Rigorously tested three times by independent third-party labs to guarantee unmatched potency and purity.
 Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle. 
\nManufactured in the USA: Since 1988, we’ve proudly produced our supplements in FDA-regulated, GMP-certified facilities, ensuring the highest quality and safety standards. 
\n100-Day Risk-Free Guarantee: We stand behind our products. If you’re not completely satisfied, contact our Santa Barbara, CA office for a full refund—no hassle, no questions asked.

A Smarter Way to Age Well

Pro Collagen Activator is designed to help restore what time naturally diminishes—by reactivating your body’s own collagen-building systems with precision. This advanced formula delivers hydroxyproline in a highly bioavailable form, combined with proline, liposomal vitamin C, and citrus bioflavonoids to fuel collagen production from multiple angles.*^2,4,6,12-16

The result is a comprehensive, inside-out approach to structural renewal—supporting the skin, joints, and full-body resilience at every stage of life.*^1-6

Whether your goal is to boost skin health, maintain connective tissue strength, or support graceful aging, Pro Collagen Activator offers a smarter, science-driven way to keep your collagen engine running strong.*^1-6

A Word from Our Chief Science Officer

“Hydroxyproline is unique to collagen—and the body is remarkably attuned to it. When collagen breaks down from age, stress, or daily wear and tear, hydroxyproline is released into the bloodstream as a biological distress signal. The body interprets this as a cue to initiate repair. By supplementing with hydroxyproline, we harness this natural signaling pathway—essentially tricking the body into ramping up collagen production in skin, joints, bones, and connective tissue. It’s like flipping your body’s collagen switch back on.”

Pioneering Longevity Since 1988

For over 36 years, ProHealth has been dedicated to crafting the world’s highest-quality supplements—rooted in innovation, integrity, and a passion for healthy aging. With a long-standing A+ rating from the Better Business Bureau, our reputation for purity and potency has made us one of the most trusted names in the industry. Our commitment to scientific rigor, premium sourcing, and results you can feel continues to drive everything we do.

Ingredient Info

\nL-Hydroxyproline: A rare amino acid that helps activate collagen-producing cells and is essential for forming collagen’s stable triple-helix structure.*^2,4,12-14\n
\nL-Proline: A foundational amino acid that the body converts into hydroxyproline when sufficient vitamin C is present.*^2,12,13\n
\nLiposomal Vitamin C: A bioavailable form of vitamin C that supports proline conversion, collagen cross-linking, and overall collagen stability.*¹⁵\n
\nCitrus Bioflavonoids: Antioxidant-active compounds that boost vitamin C absorption and help protect existing collagen from oxidative stress.*¹⁵\n

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References:

Liu H et al. Photodermatol Photoimmunol Photomed. 2024;40(1):e12931.
Li P Wu G. Amino Acids. 2018;50(1):29-38.
Chen L et al. Food Funct. 2023;14(23):10628-10638.
Ohara H et al. J Dermatol. 2010;37(4):330-338.
Barati M et al. J Cosmet Dermatol. 2020;19(11):2820-2829.
Haas E. In: Staying Healthy with Nutrition. 2006.
Martínez-Puig D et al. Nutrients. 2023;15(6):1332.
López-Martínez MI et al. Front Nutr. 2022;9:926043.
Tobin DJ. J Tissue Viability. 2017;26(1):37-46.
Oikarinen A. Photodermatol Photoimmunol Photomed. 1990;7:3-4.
Ganceviciene R et al. Dermatoendocrinol. 2012;4(3):308-319.
Wu G, et al. Amino Acids. 2011;40(4):1053-1063.
Shigemura Y, et al. J Agric Food Chem. 2009;57(2):444-449.
Asai TT et al. Int J Mol Sci. 2019;21(1):229.
Khatri M et al. Amino Acids. 2021;53(10):1493-1506.
Karna E et al. Cell Mol Life Sci. 2020;77(10):1911-1918.

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Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 60
Amount Per Serving	%DV
Vitamin C (as Liposomal Ascorbic Acid)	200 mg	222%
L-Hydroxyproline	600 mg	†
L-Proline	300 mg	†
Citrus Bioflavonoids (from Orange Peel, Lemon Peel, and Quince Fruit)	50 mg	†
† Daily Value (DV) not established.

\nREV.04.25\n

\nOTHER INGREDIENTS: Vegetable cellulose (capsule), microcrystalline cellulose, phospholipids (from sunflower lecithin), silica.
\nSUGGESTED DAILY USE: Take two (2) capsules once or twice daily, with or without food.
\nCAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.

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Pro Collagen Activator - 120 capsules

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