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Helps combat aging, improves heart health and promotes muscle strength

NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.
Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.

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Supports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)

Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar. Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)

Supports Healthy Cognition: Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7)

Supports Healthy Skin: In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (8,9)

References:

1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004

2. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

3. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521

4. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238

5. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755

6. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5

7. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442-

8. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

9. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192

10. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060

11. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

12. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90 \n
Amount Per Serving	%DV
Uthever™ β-Nicotinamide mononucleotide (NMN) \n	300 mg	†
† Daily Value not established.

REV.12.23

\nOTHER INGREDIENTS: Vegetable capsule, rice flour.\n
\nDOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
\nSUGGESTED DAILY USE: Take 1-3 capsules, with or without food, preferably in the morning. Or take as recommended by your healthcare professional.
CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product
\nNOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN\n

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Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin. NMN products, including our NMN Pro capsules, are shown to support health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in metabolism, energy production, and gene expression in the body.

Boosting NMN levels in the body means we can enhance the biosynthesis of NAD+, alleviating symptoms associated with a lack of this compound. NMN supplementation has been found to support various parameters of health such as physical endurance and muscle strength, brain health, body weight, heart health, and gene expression.

NMN Pro 300, one of our NMN capsule products, focuses on delivery into the small intestine’s Slc12a8 transporter sites, where absorption is maximized and is increased over 100 times, greatly enhancing bioavailability.

Providing Purity in our NMN Capsule Products

Unfortunately, the popularity and vast results of this amazing anti-aging molecule also means that many exploitative companies are selling products under false pretenses, claiming they are providing pure NMN products, including NMN Pro capsules.

However, these products contain little to no actual NMN dietary supplements. Even worse than making false claims, the companies often pack their products with dangerous contaminants and heavy metals.

Don’t be fooled by copycats. Our Uthever® NMN Pro capsules stand out as a brand you can trust with high-quality products containing purity and potency.

We ensure the quality of our products by having an all-star team oversee and guide each step of the Uthever® NMN developmental process, right from the initial research stages to the final production process.

The Uthever Research and Development Team is led by U.S. doctors from GlaxoSmithKline, a research-based pharmaceutical and healthcare company that has established itself as a world-class leader in both medicine and healthcare.

The Uthever Production Management Team is led by senior managers from Mars Wrigley, one of the world's largest food producers with numerous world-renowned brands.

The U.S. Pharmacopoeia (USP) is a globally recognized quality standards agency that establishes standards for pharmaceutical development and manufacturing.

Adding even more to our credibility, the Uthever Scientific Quality Standard Setting Team is under the direction of a former (USP) scientist who ensures that Uthever® NMN Pro capsules are in strict accordance with USP quality standards.

We really are a stand-out pure NMN company in a sea of fake NMN, with the credentials to help our customers trust our expertise, and benefit from NMN with confidence.

\nOnly Clincially-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.
\nUnique Delivery Method. NMN Pro 300 focuses on delivery into the small intestine’s Slc12a8 transporter sites, where absorption is maximized and is increased over 100 times, greatly enhancing bioavailability.
\nSolvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
\nQuality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
\nThird-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

\nBe Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.

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NMN Pro 300™ - 300 mg, 90 capsules

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