MTHFR Actives - L-Methylfolate + Hydroxy B12 Sublingual

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Get 2 of Methyl-Life’s® key MTHFR Active products bundled for those who are sensitive or wanting to start their methylation journey off slower.  This active-nutrients package contains 2 chewable products at lower to moderate dosages for those who tend to be more sensitive to supplements: The pure & stable L-Methylfolate for optimal absorption The rare but most well-tolerated form of B12 (as Hydroxy B12) Check out the details below regarding each product included in the bundle to learn more: L-Methylfolate 2.5 - Pure & stable L-Methylfolate - 2.5 mg Vitamin B12 Sublingual - Active Hydroxy B12 at 2.5 mg per tablet Did you know that recent research shows that taking Vitamin B12 Sublingual as an oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well -  https://pubmed.ncbi.nlm.nih.gov/30632091.   Dosage WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options. How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.  FAQ'S What is the right dosage for me? Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.  Is Methylfolate the only thing I should take if I have an MTHFR gene mutation? No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 & 4 of his video seminar. You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.  You'll find our MTHFR Newbies page is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant. What is included in the Actives for Sensitives Bundle? The Actives for Sensitives Bundle includes 2 therapeutic products which contain L-Methylfolate and Vitamin B12 Sublingual tablets.  How can I get more information on MTHFR? check out our Help for MTHFR Newbies page. How can the Actives for Sensitives Bundle benefit individuals with sensitivities? This bundle is specifically curated for individuals with sensitivities to certain forms of supplements. L-Methylfolate and Vitamin B12 Sublingual provide essential nutrients in forms that are generally well-tolerated by sensitive individuals, allowing them to support their health without discomfort. Why is L-Methylfolate important in the bundle? L-Methylfolate is crucial for methylation processes in the body, particularly for those who may have difficulty processing synthetic folic acid. The 2.5 mg dosage in this bundle provides a gentle introduction for sensitive individuals. What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you). What is the significance of Vitamin B12 Sublingual in the bundle? Vitamin B12 Sublingual is a well-tolerated form of Hydroxy B12, ideal for individuals who may experience adverse effects from other forms of B12. With a dosage of 2.5 mg per tablet, it compliments the methylation process initiated by L-methylfolate. Who should consider using the Methyl-Life® Methylation Starter Bundle? Individuals who are sensitive to supplements or those who are new to methylation support may benefit from this bundle. It offers a gentle introduction to key nutrients without overwhelming the system with high dosages. I have my 23andme test results, how can I use those to know which form of Vitamin B12 Sublingual I might best tolerate? If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of Vitamin B12 Sublingual for folks seems to be hydroxy B12. All of the genetic combinations she lists below should be able to tolerate Vitamin B12 Sublingual in the form of hydroxy B12 (which is why our methylation protocol suggests hydroxy B12 as the Vitamin B12 Sublingual form to begin with): Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems) Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation And Dr. Amy Yasko talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12: COMT V158M VDR Taq B12 Types That Should Be Tolerated – – + + (TT) All 3 types of B12 – – + – (Tt) All 3 types of B12 with less Methylcobalamin – – – – (tt) Hydroxy B12 and Adenosylcobalamin + – + + All 3 types of B12 with less Methylcobalamin + – + – Hydroxy B12 and Adenosylcobalamin + – – – Hydroxy B12 and Adenosylcobalamin + + + + Hydroxy B12 and Adenosylcobalamin + + + – Hydroxy B12 and Adenosylcobalamin + + – – Mostly Hydroxy B12

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