{"@context":"https://schema.org","@type":"Product","name":"Methylfolate - 5 mg, 60 Capsules","image":["https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH490_100mL_FRNT-600x600_REV-1024.png?v=1747081575","https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH490_SF-Shopify-600x600-REV-1024.png?v=1747081575","https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH490-COA-2024-12-30_Shopify.jpg?v=1747082487"],"description":"

Folate is a vital B vitamin that plays a key role in methylation—a critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic®, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.*

Why Quatrefolic®?

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate—the bioactive form of folate that the body uses directly, without requiring conversion. Unlike folic acid, which must go through multiple enzymatic steps to become active, Quatrefolic® is ready for immediate uptake and use at the cellular level.*

Clinically studied for enhanced bioavailability
Supports methylation pathways*
Supports healthy homocysteine balance*
Supports mood and cardiovascular health*
Essential for fetal development and reproductive health*

View Certificate of Analysis

Who It's For

This high-dose formula is ideal for individuals with increased folate needs or those with MTHFR gene variants who may have trouble converting folic acid to its usable form.*

How It Works

Folate is required to convert homocysteine into methionine—a process vital for cardiovascular and neurological function. It also supports the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which influence mood and cognition.*

What Makes Ours Better?

\nLongevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
\nTriple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
\nComplete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body. 
\nUSA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
\n100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹Bani Soheila, J Caring Sci 2013
²Mazza A. et al. Biol Regul Homeost Agents 2016
³Rima Obeid R., Herrmann W. FEBS Letters 580, 2006
⁴Stover Patrick, Curr Opin Biotechnol 2017
⁵Seshadri S. at al. N Engl J Med 2002
⁶Bottiglieri T, J Neurol Neurosurg Psychiatry 2000
⁷Thaler C.J. 2014
⁸Stover PJ. Modern Nutrition in Health and Disease 2012
⁹Tinelli C, Di Pino A Front. Nutr. 2019

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving	%DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt)	8,500 mcg DFE** (5 mg)	2,125%
* Daily Value (DV) **DFE (Dietary Folate Equivalent) \n

\nREV. 10.24
\n

\nOTHER INGREDIENTS: Vegetable cellulose (capsule), cellulose.
\nSUGGESTED DAILY USE: Take one (1) capsule daily, or as directed by your healthcare professional.
\nCAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18 or are undergoing treatment for a
medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.

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Methylfolate - 5 mg, 60 Capsules

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