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Helps combat aging, supports heart health and promotes muscle strength and cognition

NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health and body weight.
Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that may improves health and longevity by serving as a precursor to NAD+.
Liposomal form of NMN allows for increased bioavailability and enhanced absorption.

View Certificate of Analysis

Research-Supported Benefits:

\nSupports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)

Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar—a known contributor to several metabolic-related disorders. Supplemental NMN has been shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)

Supports Healthy Cognition: Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7,8,9)

Supports Healthy Skin: In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin (10, 11)

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References

1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004

2. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985

3. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755

4. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442

5. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

6. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

7. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192

8. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5

9. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060

10. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238

11. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

12. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521

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Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving	%DV
Uthever® β-Nicotinamide Mononucleotide (NMN)	300 mg	†
† Daily Value (DV) not established

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Uthever® is a registered trademark of Eepharm (Shanghai) Co., Ltd.

REV.06.25\n

\nOTHER INGREDIENTS: Sunflower lecithin, microcrystalline cellulose, hypromellose (capsule).
\nSUGGESTED DAILY USE: Take two (2) capsules per day, with or without food, preferably in the morning.
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\nCAUTION: Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place.

Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that may improve health and longevity by serving as a precursor to NAD+.
NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health and body weight.
ProHealth’s Liposomal NMN features an innovative delivery system that may help to increase the product's bioavailability (how well it’s absorbed and used by the body).

\nOnly Clinically-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published clinical study. Results of the study indicated a 38% increase in NAD+ levels and a 12-year reversal in biological age. (12)
\nUnique Liposomal Delivery Method. ProHealth’s Liposomal NMN features an innovative delivery system that may help to increase the product's bioavailability (how well it’s absorbed and used by the body).

Liposomes are nano-sized bubbles with a unique molecular structure that acts as a delivery vehicle to facilitate the transport of NMN into our cells.
The double-layered bubble safely protects the compound inside, allowing it to travel through the harsh digestive tract and bloodstream until it meets our cells. From there, the liposome merges with our cell membranes and releases the inner nutrient contents into the cell.
The body recognizes and accepts liposomal structures because they are phospholipid-based, mimicking our own cell membranes. This means compounds can be directly delivered into cells.
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\nConvenient Capsule Form. This liposomal NMN comes in capsule form, making it easy and convenient to take NMN while on the go or traveling.
\nSolvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
\nQuality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
\nThird-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Liposomal NMN Pro™ 300 - 60 capsules

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