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Protects cardiovascular tissue from free radical damage and supports a healthy inflammatory response.

Supports heart and heart function
Strengthens the body's immune system
Slows down the aging process
Supports various organ health

View Certificate of Analysis

Research-Supported Benefits:

Protects Cardiac and Endothelial Tissue. Human studies have shown that hydroxytyrosol supplementation decreases inflammatory markers. It also increases production of superoxide dismutase (SOD), the body’s own antioxidant, to reduce tissue damage.¹

Promotes Healthy Blood Markers: Hydroxytyrosol metabolites attach to excess lipids in the blood and remove them, leading to a decrease in blood lipids. This reduction can reduce the immune response which is a key factor in aging-related damage to blood vessels.¹

Decreases Free-Radical Burden: Hydroxytyrosol reduces excess free-radicals and nitric oxide, which are signaling molecules that can lead to DNA and protein damage. Additionally, it can activate certain anti-inflammatory proteins which can help improve tissue health in the blood vessels, digestive system,and liver.¹

Supports DNA Health: Activates expression of the sirtuins through the same mechanisms as caloric restriction. In addition, hydroxytyrosol encourages the destruction of abnormal cells without inhibiting the function of healthy cells.²

References:

1. Boss A, Bishop KS, Marlow G, Barnett MPG, Ferguson LR. Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients. 2016;8(8):513. doi:10.3390/nu8080513

2. Sharifi-Rad J, Rodrigues CF, Sharopov F, et al. Diet, lifestyle and cardiovascular diseases: linking pathophysiology to cardioprotective effects of natural bioactive compounds. International Journal of Environmental Research and Public Health. 2020;17(7):2326. doi:10.3390/ijerph17072326 doi:10.3390/ijerph17072326

3. Lockyer S, Yaqoob P, Spencer JPE, Rowland I. Olive leaf phenolics and cardiovascular risk reduction: Physiological effects and mechanisms of action. Nutrition and Aging. 2012;1(2):125-140. doi:10.3233/NUA-2012-0011

4. Vijakumaran U, Shanmugam J, Heng JW, et al. Effects of hydroxytyrosol in endothelial functioning: a comprehensive review. Molecules. 2023;28(4):1861. doi:10.3390/molecules28041861

5. Robles-Almazan M, Pulido-Moran M, Moreno-Fernandez J, et al. Hydroxytyrosol: Bioavailability, toxicity, and clinical applications. Food Research International. 2018;105:654-667. doi:10.1016/j.foodres.2017.11.053

6. Robles-Almazan M, Pulido-Moran M, Moreno-Fernandez J, et al. Hydroxytyrosol: Bioavailability, toxicity, and clinical applications. Food Research International. 2018;105:654-667. doi:10.1016/j.foodres.2017.11.053

Hydroxytyrosol is present in small amounts in olive oil and is thought to be one of the reasons those who eat a Mediterranean style diet experience slower aging and better health into older age.²\n
Hydroxytyrosol, a primary bioactive agent found in olive leaves and olive oil, has the greatest measured antioxidant capacity of all tested polyphenols with an ORAC score of 68,576. This small molecule is able to cross the blood-brain barrier and diffuse through tissues to capture free radicals and nitric oxygen species.¹\n
Hydroxytyrosol reduces inflammation in tissues and decreases the response of the immune system.⁴\n
Hydroxytyrosol Extreme™ is rapidly absorbed through the intestines and into circulation to deliver antioxidant and anti-inflammatory effects throughout tissues in the cardiovascular system, digestive tissue, and the liver. It facilitates more effective absorption of vitamins A, D, and K.
Hydroxytyrosol slows the aging of tissues by reducing free radical damage and enhancing transcription of sirtuins.¹\n

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving	%DV
Olive Leaf Extract 25% Hydroxytyrosol (Olea25™) Yielding 25 mg Hydroxytyrosol	100 mg	†
†Daily Value not established.

\nRev. 10.23 \n

\nOTHER INGREDIENTS: Rice flour, vegetable capsule.
\nDOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
\nSUGGESTED DAILY USE: Take 1 capsule daily, or as recommended by your healthcare professional.
\nNOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
\nCAUTION: People sensitive or allergic to olives or olive leaf should not take this product. Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications,
consult with your healthcare professional before using this product.

Better Absorption. Olea25™ proprietary extraction process yields a hydroxytyrosol concentration standardized to an unprecedented 25%, compared to other products that commonly standardize their hydroxytyrosol supplements to 6% or less. This combination helps to slow the absorption allowing it to work longer in the body.

Research-Supported. Hydroxytyrosol has been extensively studied for its cardiovascular and anti-inflammatory benefits. Hydroxytyrosol Extreme™ is formulated to have the highest potency available standardized to 25%, compared to others which are standardized to 6% or less, to promote longevity and decrease age-related loss of function through improved heart function, normal immune response, and healthy levels of inflammation.

Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.

Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Hydroxytyrosol Extreme™ - 25 mg, 90 capsules

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