{"@context":"https://schema.org","@type":"Product","name":"Full Spectrum Apigenin Plus - 250 mg, 60 capsules","image":["https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH695_175CC_FRNT_600x600-REV-1024.png?v=1740092499","https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH695_Shopify-SF-600x600-REV1024.png?v=1740092499","https://cdn.shopify.com/s/files/1/0206/3076/5668/files/PH695-COA-2025-01-24_Shopify.jpg?v=1740093691"],"description":"

Harness the Power of Apigenin for Healthy Aging

Helps maintain healthy NAD+ levels*^1-3\n
Provides antioxidant support to combat oxidative stress*^4-7\n
Supports relaxation and sleep quality*^8-13\n
Targets key pathways of healthy aging at the cellular level*^14-29*

Apigenin is a potent flavonoid commonly found in chamomile, parsley, and celery that plays a key role in cellular health, relaxation, and longevity. By targeting CD38, a major NAD+-consuming enzyme, apigenin helps sustain optimal NAD+ levels—essential for energy production and healthy aging.*^1-3

View Certificate of Analysis

\nUltra-Pure Extract: Apigenin derived from celery (Apium graveolens) seed, delivering exceptional purity and potency, rooted in centuries of traditional use.*
\nClinically Backed Strength: Each capsule provides a potent 250mg dose of apigenin, among the highest available on the market.
\nFull Spectrum Ingredients: Unlike synthetic apigenin, this blend combines pure plant-derived apigenin with organic parsley powder to deliver a wide spectrum of phytonutrients and co-factors that support optimal activity.*
\nEnhanced Absorption: Features BioPerine® black pepper extract to boost absorption and bioavailability.*³⁰\n

What Makes Ours Better?

\nDoctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.* 
\n
\nTriple Lab Tested: Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.
\nFull Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
\nUSA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
\n100-Day Risk-Free Guarantee: We're confident you’ll love our product. If you're not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.

Apigenin is a naturally occurring flavonoid found in a variety of fruits, vegetables, and herbs. Its therapeutic potential is highlighted by human clinical studies on chamomile extract, which contains apigenin as a key active ingredient. Recognized for its broad-spectrum benefits, apigenin has gained attention for its role in supporting relaxation and sleep quality. It interacts with GABA receptors in the brain, helping to foster a calm state of mind and support healthy sleep patterns—critical factors for long-term health and cognitive function.*³¹

One of apigenin's key mechanisms involves targeting CD38, an enzyme responsible for depleting NAD+, a vital molecule for energy production and cellular repair. By balancing CD38 activity, apigenin helps maintain healthy NAD+ levels, supporting mitochondrial function, DNA integrity, and overall cellular resilience as the body ages. Additionally, apigenin offers powerful antioxidant effects, neutralizing free radicals and reducing oxidative stress—both major contributors to aging and age-related decline.*^1-3

By addressing several hallmarks of aging and supporting the core pillars of health, apigenin emerges as a powerful compound for those aiming to optimize their health and longevity.*

Feel the Difference with Full Spectrum Apigenin

Helps maintain healthy NAD+ levels*
Apigenin indirectly boosts NAD+ levels by targeting CD38, a glycoprotein that consumes NAD+ during cellular processes. Research shows that mice either lacking CD38 or supplemented with apigenin have approximately 50% higher NAD+ levels, underscoring apigenin’s role in NAD+ metabolism. As CD38 activity naturally increases with age, accelerating NAD+ decline, apigenin offers a unique way to counteract this process. When paired with NAD+ precursors like NR or NMN, apigenin further optimizes NAD+ metabolism, providing additional support for cellular health and vitality.*^1-3

Provides antioxidant support to combat oxidative stress*
Apigenin, like other powerful flavonoids such as quercetin, rutin, luteolin, and EGCG, offers robust antioxidant protection, helping plants combat UV radiation, environmental stress, and free radicals. In the human body, apigenin’s electron-rich flavonoid structure performs a similar protective function—neutralizing free radicals and boosting antioxidant pathways. This support helps promote cellular health, longevity, and overall resilience against oxidative damage.*^4-7

Supports relaxation and sleep quality*
Apigenin is well-known for its ability to support relaxation and sleep quality. Research shows that higher dietary apigenin intake is linked to better sleep quality. It works by activating chloride ion channels and modulating GABAergic pathways in the brain, helping to calm neuronal activity and induce a deeper state of relaxation. Additionally, apigenin plays a role in supporting healthy cortisol levels, reducing the impact of stress and encouraging balanced, restorative sleep patterns.*^8-13

Targets key pathways of healthy aging at the cellular level*
Beyond its role in maintaining NAD+ levels—and its downstream activation of sirtuins and PARPs—apigenin plays a crucial part in cellular renewal. It helps activate autophagy, the body's natural cellular repair process that maintains healthy cell function. Additionally, apigenin has been shown to combat cellular senescence by acting as a senolytic agent, aiding in the clearance of senescent cells while buffering the effects of senescence-associated secretory phenotype (SASP) factors.*^14,15

Beyond these core actions, apigenin influences numerous other longevity pathways, including AMPK, PPARα/γ, SIRT-1, mTOR, IGF-1, immune signaling, and NF-κB, helping to optimize cellular health across multiple systems.*^16-29

New and noteworthy
Apigenin is highly active in the body, with emerging research highlighting its potential to provide a range of benefits, including neuroprotection, cardiovascular support, and metabolic health. Scientists are actively exploring its full therapeutic profile.*^{1,17,20,28,32-36}

Experience nature's calming bioflavonoid—the perfect stack to elevate your wellness routine.*

Order now and join the thousands of people who trust ProHealth for their longevity journey!

Ingredients:

\nApigenin: A powerful bioflavonoid compound found in chamomile, known for its ability to support relaxation and boost NAD+.*
\nOrganic Parsley: A source of complementary phytonutrients that amplify the full-spectrum benefits of the formula.*
\nBioPerine® Black Pepper: A patented extract that boosts the absorption and bioavailability of key ingredients.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹Escande C et al. Diabetes. 2013;62(4):1084-1093.
²Ogura Y et al. Aging.12(12), 11325–11336.
³Kellenberger E et al. Bioorg Med Chem Lett. 2011;21(13):3939-3942.
⁴Ahmad A et al. Food Chem Toxicol. 2019;127:218-227.
⁵Abid R et al. Molecules. 2022;27(13):4304.
⁶Kashyap P et al. J Food Biochem. 2022;46(4).
⁷Singh A et al. Crit Rev Food Sci Nutr. 2024;8(17):1-37.
⁸Kim J et al. Archives of Pharmacal Research. 35(2), 367–373.
⁹Amsterdam JD et al. J Clin Psychopharmacol. 2009;29(4):378-382.
¹⁰Godos J et al. Nutrients. 2020;12(5):1226.
¹¹Viola H et al. Planta Med. 1995;61(3):213-216.
¹²Ohno S et al. J Steroid Biochem Mol Biol. 2002;80(3):355-363.
¹³Cheng LC et al. Toxicol Appl Pharmacol. 2012;258(3):343-350.
¹⁴Lu J et al. Food Funct. 2020;11(10):9208-9215.
¹⁵Fan X et al. Int J Mol Sci. 2022;23(4):2176.
¹⁶Choi WH et al. Mol Nutr Food Res. 2017;61.
¹⁷Wong TY et al. Biomed Pharmacother. 2017;96:1000–1007.
¹⁸Ono K et al. J Agric Food Chem. 2011;59:13346–13352.
¹⁹Wei X et al. Clin Sci. 2017;131:567–581.
²⁰Mahajan UB et al. Int J Mol Sci. 2017;18.
²¹Wang F et al. Chem Biol Interact. 2017;275:171–177.
²²Yu W et al. Evid Based Complement Alternat Med. 2017;2017:2590676.
²³Tong X et al. Mol Carcinog. 2012;51:268–279.
²⁴Bridgeman BB et al. Cell Signal. 2016;28:460–468.
²⁵Babcook MA et al. Curr. Drug Targets. 2012.
²⁶Shukla S et al. Pharm Res. 2012;29:1506–1517.
²⁷Cardenas H et al. Int J Mol Sci. 2016;17:323.
²⁸Ren B et al. Eur J Pharmacol. 2016;773:13–23.
²⁹Kim A et al. Arch Pharmacol. 2018;391:271–283.
³⁰Dudhatra GB et al. Scientific World Journal. 2012;2012:637953.
³¹Kramer DJ et al. Front Nutr. 2024;11:1359176.
³²Nabavi SF et al. Pharmacol Res. 2018;128:359-365.
³³Han Y et al. J. Clin. Neurosci. 2017;40:157–162.
³⁴Zhang F et al. Neurol Sci. 2014;35:583–588.
³⁵Zhao L et al. Molecules. 2013;18:9949–9965.
³⁶Jung UJ et al. Nutrients. 2016;8(5):305.

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving	%DV
Organic Parsley Powder (Petroselinum crispum)	350 mg	†
Natural Apigenin (Apium graveolens extract 98%)	250 mg	†
Black Pepper (piperine) (Piper nigrum extract 95%)	3.5 mg	†
†Daily Value (DV) not established

\nREV.10.24

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\nSUGGESTED DAILY USE: Take one (1) capsule daily with food, or as recommended by your healthcare professional.
\nOTHER INGREDIENTS: Vegetable cellulose (capsule).
\n
\nDOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
\n
\nCAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.

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Full Spectrum Apigenin Plus - 250 mg, 60 capsules

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