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Discover the Power of Berberine—Advanced Metabolic Support for Healthy Aging.

Helps maintain healthy blood sugar levels*^1-6\n
Supports cardiovascular health and lipid metabolism*^1-6\n
Supports a balanced gut microbiome*^3,5,7\n
Activates AMPK, the \"longevity switch\" of cellular energy and metabolism* ^1-2\n

Berberine is a powerful metabolic optimizer that enhances the body’s ability to process carbohydrates and fats. It promotes the conversion of food into energy, supports nutrient storage and distribution, and aids systems that manage energy balance. By optimizing these key metabolic processes, berberine helps the body utilize nutrients more effectively.*

What Makes Ours Better?

\nUltra-Pure Extract: Sourced from the bark of Indian barberry (Berberis aristata), ensuring both exceptional purity and potency, backed by centuries of traditional use.* 
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\nClinical Strength: Each capsule delivers a precise 600mg dose, optimized for maximum efficacy.*
\nTargeted Support: Formulated with alpha-lipoic acid (ALA) to enhance antioxidant protection and support cellular energy.*
\nEnhanced Absorption: Features BioPerine® black pepper extract to boost nutrient absorption and bioavailability.*⁸\n

Why Choose ProHealth?

\nDoctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
\nTriple Lab Tested: Rigorously tested three times by independent third-party labs to guarantee unmatched potency and purity.
\nFull Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
\nManufactured in the USA: Since 1988, we’ve proudly produced our supplements in FDA-regulated, GMP-certified facilities, ensuring the highest quality and safety standards.
\n100-Day Risk-Free Guarantee: We stand behind our products. If you’re not completely satisfied, contact our Santa Barbara, CA office for a full refund—no hassle, no questions asked.*⁸\n

Advanced Metabolic Support for Healthy Aging
Berberine is a bioactive plant extract with a rich history of use in Ayurvedic and Chinese medicine. As a “pleiotropic” compound, it delivers a wide range of benefits and influences multiple systems in the body. While berberine is best known for supporting healthy blood sugar levels, it also plays a key role in various biochemical pathways associated with healthy aging and longevity.*^1-7,9-10

Helps maintain healthy blood sugar levels*
Berberine is widely recognized for its role in glucose support, working through multiple pathways at once. It influences glucose absorption in the intestines, supports glucose uptake in the liver and muscles, interacts with gut microbiota, influences glucose production, and helps the body use energy efficiently. The net effect is that berberine helps maintain blood sugar levels already within the normal range.*^1-6

Supports cardiovascular health and lipid metabolism*
Berberine helps maintain healthy cholesterol levels and supports blood vessels by protecting the cardiovascular system from age-related oxidative stress and inflammation. Research suggests it supports healthy blood pressure levels already within the normal range, partly by influencing nitric oxide production and helping defend against free radical damage that contributes to cardiovascular aging.*^1-6

Supports a balanced gut microbiome*
Although berberine has low bioavailability when taken orally, research has begun to explore its benefits inside the gut. Berberine appears to act as a prebiotic-like compound, supporting beneficial gut bacteria and promoting microbial diversity. Studies suggest it influences Akkermansia muciniphila, a bacterium associated with gut barrier integrity, immune function, and metabolic health. Additionally, berberine has been shown to boost gut mucin secretion, which helps maintain a balanced microbiome and supports overall digestive and metabolic health.*^3,5,7

Activates AMPK, the \"longevity switch\"*
Berberine is known to boost AMP-activated protein kinase (AMPK), which is an energy sensor that regulates metabolic changes. AMPK, which is vital for mitochondrial production, metabolic function, and cellular cleanup (autophagy). By influencing this key pathway, berberine helps optimize energy production, enhance metabolic health, and promote cellular repair, supporting the maintenance of healthy cells, DNA, and mitochondria. These effects make berberine a powerful natural compound for promoting longevity, health span, and vitality.*^1,2

Beyond activating the AMPK pathway, berberine has been shown to rejuvenate aging senescent cells in recent research by influencing other key longevity pathways, including PCG1-α, SIRT-1, and mTOR.*³

Discover the power of Berberine—ProHealth’s trusted formula for advanced metabolic support and healthy aging, featuring TikTok’s trending botanical.

Ingredients:

\nBerberine: A yellow plant alkaloid that supports healthy blood sugar levels, metabolic function, and longevity by activating AMPK.*
\nAlpha Lipoic Acid: A potent free radical scavenger that aids in cellular energy production.*
\nBioPerine® Black Pepper: A patented extract that boosts the absorption and bioavailability of key ingredients.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015;3(4):e53. Published 2015 Dec 31. doi:10.15190/d.2015.45
Koppen LM, Whitaker A, Rosene A, Beckett RD. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid Based Complementary Altern Med. 2017;22(4):956-968. doi:10.1177/2156587216687695
Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013
Baziar N, Nasli-Esfahani E, Djafarian K, et al. The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Oxid Med Cell Longev. 2020;2020:5850865. Published 2020 Mar 9. doi:10.1155/2020/5850865

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Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving	%DV
Chromium (as Chromium Picolinate)	200 mcg	571%
Berberine HCl (from Berberis aristata Bark Extract)	600 mg	†
BioPerine® Black Pepper Fruit Extract (95% Piperine)	3.4 mg	†
† Daily Value (DV) not established

Rev. 09.25

\nBioPerine® is a registered trademark of Sabinsa, Co.

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\nOTHER INGREDIENTS: Hypromellose (capsule), rice flour.
\nSUGGESTED DAILY USE: Take one (1) capsule 2-3 times per day with food.
\nCAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
\nNOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN\n

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Berberine Pro - 1,200 mg per day, 60 capsules

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