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Moderate dose 5 methylfolate for healthy methylation, homocysteine and natural mood support.

Bioactive folate (5 mthf L-Methylfolate) uniquely formulated with the internationally-patented Magnafolate® PRO.

5 methylfolate is the predominant form of folate circulating in the body and used for biological processes¹.

5 Methylfolate 5.6mg shown to slow cognitive decline in patients with dementia².

5 Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier³.

Support for brain function⁴
Supports cardiovascular health⁵
Support for healthy immune function⁶
Supports nerve function⁷
Support for preconception, pregnancy, and fetal health⁸
Involved in maintaining healthy homocysteine levels⁹
Essential nutrient required for healthy DNA and neurotransmitter synthesis¹⁰
Suitable for people with MTHFR mutations¹¹

A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviors resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.

Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.¹⁹

Product details

Key ingredient: Folate 5,000 mcg (L-5-Methyltetrahydrofolate, Calcium as Magnafolate® PRO)

5 Methylfolate 5 mg is a highly bioactive form of folate made with the purest methylfolate available¹².

Maximum absorption and bioavailability
No prescription required
Available in 2.5mg, 3mg+B12 , 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
Rigorously tested for consistency, purity, safety, and potency

Why take methylfolate?

Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.

Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)¹³.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%¹⁴.

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness¹⁵. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses¹⁶.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate¹⁰.

Methyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why Magnafolate® PRO?

Methyl-Life’s® 5 Methylfolate 5 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as the world’s purest methylfolate (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).

Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body¹⁷.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation¹⁸.

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Dosage

WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methyla t ion protocol as a potential step by step guide to some dosing options.

How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.

SUPPLEMENT FACTS

\nSUGGESTED USE: Consult with your healthcare practitioner before using this product. See methyl-life.com/dosage for more recommendations.\n

Great for teeth (contains xylitol). KEEP THIS PRODUCT AWAY FROM PETS.

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SUPPLEMENT FACTS
\n Serving Size: 1 Chewable Tablet \n
	Amount per Serving	% Daily Value
Folate	8,500 mcg DFE	2,125%
(5 mg L-Methylfolate from 7 mg of Cerebrofolate®)	\n \n	\n \n

OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).

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Not a significant source of total sugars.

Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMO's. No artificial ingredients or colorings.

Research

FAQ'S

$\"Methylfolate$ What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

$\"Methylfolate$ Is 5 Methylfolate the only thing I should take if I have an MTHFR gene mutation?

No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 & 4 of his video seminar.

You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.

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You'll find our MTHFR Newbies page is very helpful as well. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

$\"Methylfolate$ What do doctors have to say about MTHFR and how to treat it?

Go to A Doctor Explains and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of Methylfolate.

$\"Methylfolate$ How can I get more information on MTHFR?

check out our Help for MTHFR Newbies page.

$\"Methylfolate$ Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?

\nBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of 5 methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.\n

$\"Methylfolate$ What is 5 Methylfolate 5 mg by Methyl-Life?

\n5 Methylfolate 5 mg by Methyl-Life is a high-strength 5 methylfolate supplement, providing a bioavailable form of folate that supports methylation processes in the body, crucial for various biochemical reactions.\n

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$\"Methylfolate$ How does 5 Methylfolate 5 mg benefit health?

5 Methylfolate 5 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.

$\"Methylfolate$ Can 5 Methylfolate 5 mg help with depression?

5 Methylfolate 5 mg may potentially help with depression, particularly in individuals with certain genetic variations affecting folate metabolism or those with folate deficiencies. Research suggests that 5 methylfolate supplementation may support mood regulation and mental health, although individual responses can vary. It's essential to consult with a healthcare professional for personalized advice and treatment options for depression.

$\"Methylfolate$ Who can benefit from taking 5 Methylfolate 5 mg?

Individuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from 5 Methylfolate 5 mg supplementation.

$\"Methylfolate$ How long does it take to experience the benefits of 5 Methylfolate 5 mg?

Individual responses may vary, but some users report noticing improvements in energy levels and overall well-being over just five weeks of starting 5 Methylfolate 5 mg supplementation.

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5 Methylfolate: 5-mthf L-Methylfolate 5 mg

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